Well, for the last 2+ hours I've been studying the datasheet and brushing up on my (not so good to start with) Peltier knowledge, and I have to say I'm more skeptical than ever.
For starters, the datasheet itself is way too incomplete. No circuit diagram, no working principle, nothing. Just a max parameter table, and 2 diagrams per module.
Then, the diagrams are also incomplete, and the one on the right is downright funny.
A negative ∆T? What does that mean, that the cold side gets hot, and the hot side gets cold?
And then you have the scale...Let's suppose the "0" is between -13 and 7, right? So then you have 7, 27 and..."0"? The relation between ∆T and power consumption is supposed to be fairly linear, so how can they have straight current lines when the cited ∆T parameters are nothing if not chaotic?
And what's the ∆T unit? °C? °F? °K?
Anyways, let's work (or try to work) with what we have. The diagram on the right gives you for a 25 A consumption on 12.5 V (approx), a ∆T of 27. Now, assuming a 10% error (very conveniently...

), we can go for the 30 ∆T in the diagram on the left, and see that for a 25 A current we get a Qc of 120 W, Which is ALL you can get from one TEC on 12.5 V. To get 480 W Qc you'd need 4 TEC's in parallel.
But here's where it gets good: ∆T is the temperature difference between cold and hot side of the TEC, not its cooling capacity. What I mean is, if you are gonna water cool the TEC (which is by far the best, more stable way), the water will, inevitably, get hot to an extent. You will have to take that extra heat, as well as the thermal resistance of the heatsinks into the equation.
So, to make it short:
I don't trust that datasheet. The information is incomplete, and badly presented.
You're about to embark in a built that's a lot more complicated than it seems. I'd recommend you to build a prototype at home, MEASURE EVERYTHING, including power consumption, real ∆T when in use, and how much time it takes to cool down a small room in how many degrees (the consensus seems to be that it takes more cooling power to cool down a car than a small room). Cool down the TEC with HOT water from the faucet, to mimic what you'll have in a closed system in the car.
Then, if the manufacturer's claims are accurate (I doubt it), you can make an informed decision as to what you want to do.
Besides, look at their address: "2 shady"? What's that, a coincidence or a warning?
